Killer Activities in Mice
نویسنده
چکیده
The present stttdy wtts undertaken to eratnine the effects of cell.fraction.s 0f Eubacteriuttr lenturtt, especially cell wall and fraction 2 (cytoplasuic rnernbrane) on Ehrlich asciîes tuntorbearing nice. AII fraction.s etcept cell wall and fraction 2 4kl not effectively inhibit the Ehrlich ascites tunror Srowth in ICR tnice. Inlratunoral iniectiort of cell wall of Eubacteriuril lentu,,t at a lose of at least 100 pg sisnificantly inhibited the twnor Slrowth 21 days afler tunor inoculating and prolonged the survival tirne of nice. Intravenous injection of cell wall at a dose of at least 2OO pS was effective in prolonging the survival titrte of tutttor-bearing trtice. Moreover, the efîects of intraperitoneal treatntent by cell wall orfractiorr 2 of Eubacteriun lentun on uacrophage activities ofperitoneal eru4ate cavity 1nfC1 cells was eranùned. The results obtained showed that both ceII wall attdfractiotr 2 have the ability to etiltance the peritoneal tnacrophage acfiviry in Balb/c nùce. Furthertnore, cell ntediated cytotoxicity at single cell levels against YAC-l lytnphotna as target cell when treoted with cell wall orfraction 2 and the kinetic.s of natural kiUer (NK) activity of spleen cells were observe1. These results s1,ggest that both cell wall andfraction 2 are potent activators of natural kilter (NK) of spleen cells in CtH/He rnice.
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